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USP10 抗体 (N-Term)

Name: USP10 抗体 (N-Term)
SKU: ABIN6265909
Availability: OutOfStock

USP10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

Western blot analysis USP10 using HuvEc whole cell lysates (USP10 抗体 (N-Term))

1 image

产品编号 ABIN6265909

发货至: 中国

Datasheet as PDF

抗原 See all USP10 抗体

USP10 (Ubiquitin Specific Peptidase 10 (USP10))
抗原表位
7

7

6

6

6

4

3

3

3

2

2

1

1

1

1

1

1
N-Term
适用
70

25

24

5

3

3

2

2

2

2

1

1

1

1
人, 小鼠, 大鼠
宿主
62

8
兔
Compatible Secondaries
克隆类型
54

16
多克隆
标记
36

5

4

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This USP10 antibody is un-conjugated
应用范围
58

20

15

14

10

9

6

5

2

2

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

特异性

USP10 Antibody detects endogenous levels of total USP10.

预测反应

Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human USP10, corresponding to a region within N-terminal amino acids.

亚型

IgG

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USP10 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B8 unconjugated

anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 1-798) antibody
USP10 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 10 (USP10) antibody
USP10 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 301-350) antibody
USP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 487-536) antibody
USP10 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, 非洲爪蟾, Bat, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 10 (USP10) (AA 499-798) antibody
USP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

USP10 (Ubiquitin Specific Peptidase 10 (USP10))

别名

USP10 (USP10 产品)

别名

T4F9.30 antibody, T4F9_30 antibody, ubiquitin-specific protease 9 antibody, ubpo antibody, USP10 antibody, id:ibd1190 antibody, wu:fc19h08 antibody, wu:fc76g05 antibody, wu:fi11g01 antibody, UBPO antibody, 2610014N07Rik antibody, Uchrp antibody, mKIAA0190 antibody, usp10-A antibody, ubiquitin specific peptidase 10 antibody, universal stress protein UspA antibody, ubiquitin-specific protease 9 antibody, ubiquitin carboxyl-terminal hydrolase 10 antibody, ubiquitin specific peptidase 10 S homeolog antibody, USP10 antibody, RR_RS14970 antibody, UBP9 antibody, PTRG_07201 antibody, MGYG_06403 antibody, usp10 antibody, Usp10 antibody, usp10.S antibody

背景

Description: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).
Gene: USP10

分子量

87 kDa

基因ID

9100

UniProt

Q14694