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ZFP36L1 抗体 (Internal Region)

Name: ZFP36L1 抗体 (Internal Region)
SKU: ABIN6265589
Availability: OutOfStock

ZFP36L1 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of TIS11B using Jurkat whole cell lysates (ZFP36L1 抗体 (Internal Region))

ABIN6272445 staining RAW264. (ZFP36L1 抗体 (Internal Region))

IF/ICC

2 images

产品编号 ABIN6265589

发货至: 中国

Datasheet as PDF

抗原 See all ZFP36L1 抗体

ZFP36L1 (ZFP36 Ring Finger Protein-Like 1 (ZFP36L1))
抗原表位
15

14

13

10

5

3

3

2

2

2

2

2

1

1

1

1

1
Internal Region
适用
46

46

40

10

9

8

7

6

4

4

4

2

1
人, 小鼠
宿主
70

3
兔
Compatible Secondaries
克隆类型
71

2
多克隆
标记
40

5

4

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This ZFP36L1 antibody is un-conjugated
应用范围
48

36

16

15

15

10

6

5

3

2

1

1

1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

TIS11B Antibody detects endogenous levels of total TIS11B.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human TIS11B, corresponding to a region within the internal amino acids.

亚型

IgG

Top Product

Discover our top product ZFP36L1 Primary Antibody
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 1-108) antibody
ZFP36L1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1A3 unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (Middle Region) antibody
ZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 64-93), (N-Term) antibody
ZFP36L1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40956 unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 66-115) antibody
ZFP36L1 适用: 人, 犬, Cow, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 46-95) antibody
ZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 兔, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (N-Term) antibody
ZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 1-108) antibody
ZFP36L1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (Ser189) antibody
ZFP36L1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (AA 46-95) antibody
ZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 兔, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) (C-Term) antibody
ZFP36L1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

ZFP36L1 (ZFP36 Ring Finger Protein-Like 1 (ZFP36L1))

别名

ZFP36L1 (ZFP36L1 产品)

别名

ZFP36L1 antibody, berg36 antibody, brf1 antibody, c3h-2 antibody, cmg1 antibody, erf-1 antibody, erf1 antibody, rnf162b antibody, tis11b antibody, BRF1 antibody, Berg36 antibody, ERF-1 antibody, ERF1 antibody, RNF162B antibody, TIS11B antibody, cMG1 antibody, Brf1 antibody, TIS11b antibody, AW742437 antibody, AW743212 antibody, D530020L18Rik antibody, cb198 antibody, cb480 antibody, fk89d11 antibody, id:ibd1247 antibody, sb:cb198 antibody, sb:cb480 antibody, wu:fb80h11 antibody, wu:fb92f07 antibody, wu:fk89d11 antibody, zfp36l1 antibody, zfp36l2 antibody, zgc:153979 antibody, fc06f10 antibody, wu:fc06f10 antibody, zfp36l1l antibody, zgc:77882 antibody, ZFP36 ring finger protein-like 1 S homeolog antibody, ZFP36 ring finger protein like 1 antibody, zinc finger protein 36, C3H type-like 1 antibody, zinc finger protein 36, C3H type-like 1a antibody, BRF1, RNA polymerase III transcription initiation factor subunit antibody, transcription factor IIIB 90 kDa subunit antibody, zinc finger protein 36, C3H type-like 1b antibody, zfp36l1.S antibody, ZFP36L1 antibody, Zfp36l1 antibody, zfp36l1a antibody, BRF1 antibody, LOC100350146 antibody, zfp36l1b antibody

背景

Description: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing, modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).
Gene: ZFP36L1

分子量

36kDa

基因ID

677

UniProt

Q07352