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TEK 抗体 (C-Term)

Name: TEK 抗体 (C-Term)
SKU: ABIN6265567
Availability: OutOfStock

This anti-TEK antibody is a 兔多克隆 antibody detecting TEK in WB, ELISA, IHC, ICC 和 IF. Suitable for 人, 小鼠和大鼠.

Western blot analysis of Tie-2 using HUVEC whole cell lysates (TEK 抗体 (C-Term))

ABIN6277714 at 1/100 staining Human lymph node tissue by IHC-P. (TEK 抗体 (C-Term))

IHC

2 images

产品编号 ABIN6265567

发货至: 中国

Quick Overview for TEK 抗体 (C-Term) (ABIN6265567)

抗原

See all TEK 抗体

TEK (TEK Tyrosine Kinase, Endothelial (TEK))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This TEK antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Discover our top product TEK Primary Antibody

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C-Term

特异性

TIE2 Antibody detects endogenous levels of total TIE2.

预测反应

Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human TIE2, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 66-185) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A5 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 571-748) antibody
TEK 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3F5B9 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789) antibody
TEK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 401-550) antibody
TEK 适用: 人, 小鼠, 大鼠, Cow ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 286-465) antibody
TEK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) antibody
TEK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G6 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 500-750) antibody
TEK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 758-789), (C-Term) antibody
TEK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01525-01526 unconjugated

anti-TEK Tyrosine Kinase, Endothelial (TEK) (AA 160-194), (N-Term) antibody
TEK 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB30729 unconjugated

应用备注

WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

TEK (TEK Tyrosine Kinase, Endothelial (TEK))

别名

TEK

背景

Description: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1.
Gene: TEK

分子量

126 kDa

基因ID

7010

UniProt

Q02763

途径

RTK signaling, Growth Factor Binding