SYVN1 抗体 (Internal Region)
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- 抗原 See all SYVN1 抗体
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SYVN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- SYVN1 Antibody detects endogenous levels of total SYVN1.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SYVN1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SYVN1 Primary Antibody
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anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617), (C-Term) antibody
SYVN1 适用: 人, 小鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal RB4822 unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617) antibodySYVN1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibodyVerified SYVN1 适用: 人, 大鼠 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 531-617) antibodySYVN1 适用: 人, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 338-487) antibodySYVN1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 1-617) antibodySYVN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibodySYVN1 适用: 人, 小鼠, 大鼠, 马, 犬, Cow, 兔, Bat, 猴, 斑马鱼, Hamster, 非洲爪蟾 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 238-318) antibodySYVN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H4 unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 501-550) antibodySYVN1 适用: 人, 小鼠, 大鼠, 马, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 371-420) antibodySYVN1 适用: 人, 小鼠, 大鼠, 马, 犬, 豚鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
- 别名
- SYVN1 (SYVN1 产品)
- 别名
- DER3 antibody, HRD1 antibody, hrd1 antibody, 1200010C09Rik antibody, AW211966 antibody, C85322 antibody, D530017H19Rik antibody, Hrd1 antibody, RGD1310488 antibody, syvn1 antibody, syvn1-a antibody, syvn1-b antibody, wu:fk91f10 antibody, zgc:55735 antibody, zgc:77108 antibody, synoviolin 1 antibody, synovial apoptosis inhibitor 1, synoviolin antibody, synoviolin 1 S homeolog antibody, SYVN1 antibody, syvn1 antibody, Syvn1 antibody, syvn1.S antibody
- 背景
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Description: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity).
Gene: SYVN1
- 分子量
- 68-76 kDa
- 基因ID
- 84447
- UniProt
- Q86TM6
- 途径
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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