SMURF2 抗体 (Internal Region)
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- 抗原 See all SMURF2 抗体
- SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
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抗原表位
- Internal Region
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMURF2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- SMURF2 Antibody detects endogenous levels of total SMURF2.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SMURF2, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SMURF2 Primary Antibody
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anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 601-700) antibody
SMURF2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) antibodySMURF2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 702-731), (C-Term) antibodySMURF2 适用: 人, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB4107-4108 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 1-748) antibodySMURF2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) antibodySMURF2 适用: 人 WB 宿主: 小鼠 Monoclonal 1826CT865-51-28 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 150-250) antibodySMURF2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (N-Term) antibodySMURF2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (C-Term) antibodySMURF2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC 1:100-500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
- 别名
- SMURF2 (SMURF2 产品)
- 别名
- SMURF2 antibody, 2810411E22Rik antibody, AI558114 antibody, AI649275 antibody, RGD1310067 antibody, wu:fb82a11 antibody, wu:fc41c02 antibody, SMAD specific E3 ubiquitin protein ligase 2 antibody, SMAD specific E3 ubiquitin protein ligase 2 S homeolog antibody, SMURF2 antibody, smurf2 antibody, Smurf2 antibody, smurf2.S antibody
- 背景
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Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Gene: SMURF2
- 分子量
- 86 kDa
- 基因ID
- 64750
- UniProt
- Q9HAU4
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