SMARCA5 抗体 (C-Term)
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- 抗原 See all SMARCA5 抗体
- SMARCA5 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 5 (SMARCA5))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMARCA5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- SMARCA5 Antibody detects endogenous levels of total SMARCA5.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SMARCA5, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SMARCA5 Primary Antibody
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SMARCA5 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 5 (SMARCA5))
- 别名
- SMARCA5 (SMARCA5 产品)
- 别名
- fb26d12 antibody, fb49g04 antibody, chunp6878 antibody, im:7146484 antibody, wu:fb26d12 antibody, wu:fb49g04 antibody, zgc:158434 antibody, smarca5 antibody, iswi antibody, SMARCA5 antibody, hiswi antibody, snf2h antibody, hsnf2h antibody, wcrf135 antibody, MGC79455 antibody, ISWI antibody, SNF2H antibody, WCRF135 antibody, hISWI antibody, hSNF2H antibody, 4933427E24Rik antibody, D030040M08Rik antibody, D330027N15Rik antibody, MommeD4 antibody, Snf2h antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 S homeolog antibody, smarca5 antibody, smarca5.S antibody, SMARCA5 antibody, Smarca5 antibody
- 背景
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Description: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin, this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
Gene: SMARCA5
- 分子量
- 122kDa
- 基因ID
- 8467
- UniProt
- O60264
- 途径
- Chromatin Binding
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