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- 抗原 See all SIAH1 抗体
- SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
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抗原表位
- N-Term
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIAH1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- SIAH1 Antibody detects endogenous levels of total SIAH1.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SIAH1, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SIAH1 Primary Antibody
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anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (N-Term) antibody
Verified SIAH1 适用: 人, 大鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (AA 1-313) antibodySIAH1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (AA 1-110) antibodySIAH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C5 unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (N-Term) antibodySIAH1 适用: 人, 大鼠, 小鼠, 犬, Cow, 斑马鱼, 马, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (AA 191-240) antibodySIAH1 适用: 人, 大鼠, 小鼠, 犬, Cow, 斑马鱼, 马, 豚鼠, 兔, 非洲爪蟾, 小鸡, Pig, Bat, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (C-Term) antibodySIAH1 适用: 人, 大鼠, 小鼠, 犬, Cow, 斑马鱼, 马, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (AA 201-282) antibodySIAH1 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (AA 1-313) antibodySIAH1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (AA 1-110) antibodySIAH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F26 unconjugated
anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (N-Term) antibodySIAH1 适用: 人, 大鼠, 小鼠, 犬, Cow, 斑马鱼, 马, 豚鼠, 非洲爪蟾, 小鸡, Pig, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
- 别名
- SIAH1 (SIAH1 产品)
- 别名
- SIAH antibody, Siah1 antibody, Siah1a antibody, id:ibd2635 antibody, zgc:56026 antibody, SIAH1A antibody, siah antibody, E3 ubiquitin-protein ligase Siah1 antibody, E3 ubiquitin-protein ligase siah-1 antibody, siah E3 ubiquitin protein ligase 1 antibody, siah E3 ubiquitin protein ligase 1 L homeolog antibody, Tsp_03055 antibody, siah-1 antibody, Siah1 antibody, siah1 antibody, SIAH1 antibody, siah1.L antibody
- 背景
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Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.
Gene: SIAH1
- 分子量
- 31kDa
- 基因ID
- 6477
- UniProt
- Q8IUQ4
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