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SENP6 抗体 (Internal Region)

SENP6 适用: 人, 小鼠 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6264987
发货至: 中国
  • 抗原 See all SENP6 抗体
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    抗原表位
    • 13
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 47
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 43
    • 2
    • 2
    克隆类型
    • 45
    • 2
    多克隆
    标记
    • 22
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SENP6 antibody is un-conjugated
    应用范围
    • 31
    • 25
    • 19
    • 8
    • 5
    • 4
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    特异性
    SENP6 Antibody detects endogenous levels of total SENP6.
    预测反应
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human SENP6, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product SENP6 Primary Antibody
  • 应用备注
    IHC 1:50-1:200, WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    别名
    SENP6 (SENP6 产品)
    别名
    SSP1 antibody, SUSP1 antibody, 2810017C20Rik antibody, E130319N12Rik antibody, Susp1 antibody, mKIAA0797 antibody, fc83h02 antibody, im:7148342 antibody, wu:fc83h02 antibody, zgc:171230 antibody, SUMO1/sentrin specific peptidase 6 antibody, SUMO/sentrin specific peptidase 6 antibody, SUMO1/sentrin specific peptidase 6a antibody, SENP6 antibody, Senp6 antibody, senp6a antibody
    背景

    Description: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

    Gene: SENP6

    分子量
    126kDa
    基因ID
    26054
    UniProt
    Q9GZR1
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