SDCBP 抗体 (Internal Region)
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- 抗原 See all SDCBP 抗体
- SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))
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抗原表位
- Internal Region
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SDCBP antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- SDCBP Antibody detects endogenous levels of total SDCBP.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SDCBP, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SDCBP Primary Antibody
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))
- 别名
- SDCBP (SDCBP 产品)
- 别名
- MDA-9 antibody, ST1 antibody, SYCL antibody, TACIP18 antibody, Sycl antibody, syntenin-1 antibody, mda-9 antibody, st1 antibody, sycl antibody, tacip18 antibody, MGC81274 antibody, syntenin antibody, wu:fc51c03 antibody, wu:fk31e01 antibody, zgc:55679 antibody, zgc:77716 antibody, sb:eu862 antibody, si:dkey-235k4.1 antibody, syndecan binding protein antibody, syndecan binding protein L homeolog antibody, syndecan binding protein (syntenin) 2 antibody, syndecan binding protein (syntenin) antibody, SDCBP antibody, Sdcbp antibody, sdcbp.L antibody, LOC732879 antibody, sdcbp2 antibody, sdcbp antibody
- 背景
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Description: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
Gene: SDCBP
- 分子量
- 32kDa
- 基因ID
- 6386
- UniProt
- O00560
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