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RNF41 抗体 (Internal Region)

RNF41 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6264789
发货至: 中国
  • 抗原 See all RNF41 抗体
    RNF41 (Ring Finger Protein 41 (RNF41))
    抗原表位
    • 8
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 35
    • 15
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 31
    • 4
    克隆类型
    • 34
    • 1
    多克隆
    标记
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RNF41 antibody is un-conjugated
    应用范围
    • 28
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    特异性
    RNF41 Antibody detects endogenous levels of total RNF41.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human RNF41, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product RNF41 Primary Antibody
  • 应用备注
    WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    RNF41 (Ring Finger Protein 41 (RNF41))
    别名
    RNF41 (RNF41 产品)
    别名
    FLRF antibody, NRDP1 antibody, 2210404G21Rik antibody, 4930511A05Rik antibody, 4933415P08Rik antibody, D10Ertd722e antibody, Nrdp1 antibody, wu:fi13f07 antibody, wu:fi25b06 antibody, zgc:55389 antibody, flrf antibody, ring finger protein 41 antibody, ring finger protein 41 S homeolog antibody, ring finger protein 41, E3 ubiquitin protein ligase antibody, RNF41 antibody, Rnf41 antibody, rnf41 antibody, rnf41.S antibody
    背景

    Description: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

    Gene: RNF41

    分子量
    36 kDa
    基因ID
    10193
    UniProt
    Q9H4P4
    途径
    SARS-CoV-2 Protein Interactome
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