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RBM4 抗体 (Internal Region)

RBM4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6264671
发货至: 中国
  • 抗原 See all RBM4 抗体
    RBM4 (RNA Binding Motif Protein 4 (RBM4))
    抗原表位
    • 8
    • 7
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 29
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 28
    • 1
    克隆类型
    • 28
    • 1
    多克隆
    标记
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    This RBM4 antibody is un-conjugated
    应用范围
    • 25
    • 21
    • 6
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    RBM4 Antibody detects endogenous levels of total RBM4.
    预测反应
    Pig,Bovine,Horse,Sheep,Dog
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human RBM4, corresponding to a region within the internal amino acids.
    亚型
    IgG
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    RBM4 (RNA Binding Motif Protein 4 (RBM4))
    别名
    RBM4 (RBM4 产品)
    别名
    rbm4 antibody, rna-bp4 antibody, wu:fc31f07 antibody, wu:fc57h11 antibody, zgc:56302 antibody, LARK antibody, RBM4A antibody, ZCCHC21 antibody, ZCRB3A antibody, 4921506I22Rik antibody, Lark1 antibody, Mlark antibody, Rbm4a antibody, lark antibody, Rbm4 antibody, RNA binding motif protein 4.1 antibody, RNA binding motif protein 4 antibody, RNA-binding protein 14 antibody, RNA-binding protein lark antibody, rbm4.1 antibody, RBM4 antibody, LOC610648 antibody, Rbm4 antibody, LARK antibody
    背景

    Description: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.

    Gene: RBM4

    分子量
    40 kDa
    基因ID
    5936
    UniProt
    Q9BWF3
    途径
    Regulation of Muscle Cell Differentiation, Photoperiodism
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