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SLC26A5 抗体 (Internal Region)

SLC26A5 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6264415
发货至: 中国
  • 抗原 See all SLC26A5 抗体
    SLC26A5 (Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5))
    抗原表位
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 18
    • 13
    • 13
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 15
    • 2
    • 1
    克隆类型
    • 17
    • 1
    多克隆
    标记
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLC26A5 antibody is un-conjugated
    应用范围
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    特异性
    Prestin Antibody detects endogenous levels of total Prestin.
    预测反应
    Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human Prestin, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product SLC26A5 Primary Antibody
  • 应用备注
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    SLC26A5 (Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5))
    别名
    SLC26A5 (SLC26A5 产品)
    别名
    pres antibody, fb73d12 antibody, fb74g12 antibody, wu:fb73d12 antibody, wu:fb74g12 antibody, DFNB61 antibody, PRES antibody, Pres antibody, prestin antibody, solute carrier family 26 (anion exchanger), member 5 antibody, solute carrier family 26 member 5 antibody, solute carrier family 26, member 5 antibody, slc26a5 antibody, SLC26A5 antibody, Slc26a5 antibody
    背景

    Description: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).

    Gene: SLC26A5

    分子量
    81 kDa
    基因ID
    375611
    UniProt
    P58743
    途径
    Sensory Perception of Sound, Dicarboxylic Acid Transport
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