PIN1 抗体 (N-Term)
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- 抗原 See all PIN1 抗体
- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Pin1 Antibody detects endogenous levels of total Pin1.
- 预测反应
- Zebrafish,Bovine,Sheep,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human Pin1, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PIN1 Primary Antibody
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anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 30-56) antibody
PIN1 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) antibodyPIN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 30-56) antibodyPIN1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB22881 unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) antibodyPIN1 适用: 人 WB, IHC, IF, ICC, IHC (p) 宿主: 小鸡 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (pSer16) antibodyPIN1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (Internal Region) antibodyPIN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) antibodyPIN1 适用: 人, 小鼠, 大鼠, Green Monkey IHC (p), IF (cc) 宿主: 小鼠 Monoclonal 5F5 unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 2-163) antibodyPIN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) antibodyPIN1 适用: 人 ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 64-163) antibodyPIN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5A8 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
- 别名
- PIN1 (PIN1 产品)
- 别名
- DOD antibody, UBL5 antibody, dod antibody, ubl5 antibody, pin1 antibody, pin1a antibody, 0610025L01Rik antibody, D9Bwg1161e antibody, pin1b antibody, zgc:73206 antibody, PPIase pin1 antibody, MdPin1 antibody, Pin1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog antibody, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog antibody, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, peptidyl-prolyl cis-trans isomerase Pin1 antibody, PIN1 antibody, Pin1 antibody, pin1 antibody, pin1.S antibody, pin1.L antibody, ppiD antibody, PITG_11123 antibody, LOC103419188 antibody
- 背景
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Description: Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354).
Gene: PIN1
- 分子量
- 18kDa
- 基因ID
- 5300
- UniProt
- Q13526
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