PIAS2 抗体
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- 抗原 See all PIAS2 抗体
- PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
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适用
- 人, 小鼠, 大鼠, 猴
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIAS2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- PIAS2 antibody detects endogenous levels of total PIAS2
- 交叉反应
- 人, 猴, 小鼠, 大鼠
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PIAS2
- 亚型
- IgG
- Top Product
- Discover our top product PIAS2 Primary Antibody
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anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 385-473) antibody
PIAS2 适用: 人 WB, ELISA, IF, PLA, RNAi 宿主: 小鼠 Monoclonal 1F7 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 适用: 人, 小鼠, 犬, Cow, 兔, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 109-140), (N-Term) antibodyPIAS2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0678 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (N-Term) antibodyPIAS2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 适用: 人, 小鼠, 犬, Cow, 兔, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (N-Term) antibodyPIAS2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 适用: 小鼠, 大鼠, 犬, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500~1:3000, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
- 有效期
- 12 months
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- 抗原
- PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
- 别名
- PIAS2 (PIAS2 产品)
- 别名
- MGC83751 antibody, piasx antibody, wu:fi05f09 antibody, PIAS2 antibody, 6330408K17Rik antibody, AI462206 antibody, ARIP3 antibody, AU018068 antibody, Dib antibody, Miz1 antibody, PIASxalpha antibody, PIASxb antibody, PIASxbeta antibody, SIZ2 antibody, DIP antibody, MIZ antibody, MIZ1 antibody, PIASX antibody, PIASX-ALPHA antibody, PIASX-BETA antibody, ZMIZ4 antibody, protein inhibitor of activated STAT 2 L homeolog antibody, protein inhibitor of activated STAT 2 antibody, protein inhibitor of activated STAT, 2 antibody, pias2.L antibody, PIAS2 antibody, pias2 antibody, Pias2 antibody
- 背景
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Description: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
Gene: PIAS2
- 分子量
- 68kDa
- 基因ID
- 9063
- UniProt
- O75928
- 途径
- JAK/STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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