电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

PI3K p85 alpha/gamma 抗体

PI3K p85a/g 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6264193
发货至: 中国
  • 抗原 See all PI3K p85 alpha/gamma (PI3K p85a/g) products
    PI3K p85 alpha/gamma (PI3K p85a/g) (Phosphoinositide 3 Kinase, p85 alpha/gamma (PI3K p85a/g))
    适用
    • 22
    • 22
    • 22
    • 16
    • 5
    • 2
    人, 小鼠, 大鼠, 猴
    宿主
    • 22
    克隆类型
    • 22
    多克隆
    标记
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PI3K p85 alpha/gamma antibody is un-conjugated
    应用范围
    • 22
    • 14
    • 13
    • 13
    • 9
    • 6
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    特异性
    PI3-kinase p85-alpha/gamma Antibody detects endogenous levels of total PI3-kinase p85-alpha/gamma
    交叉反应
    人, 猴, 小鼠, 大鼠
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human PI3-kinase p85-alpha/gamma
    亚型
    IgG
  • 应用备注
    WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C.Stable for 12 months from date of receipt
    有效期
    12 months
  • Chai, Bai, Li, Chen, Zhang: "Biological functions of lung cancer cells are suppressed in co-culture with mesenchymal stem cells isolated from umbilical cord." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 1076-1080, (2018) (PubMed).

  • 抗原
    PI3K p85 alpha/gamma (PI3K p85a/g) (Phosphoinositide 3 Kinase, p85 alpha/gamma (PI3K p85a/g))
    别名
    PI3-kinase p85-alpha/gamma (PI3K p85a/g 产品)
    背景

    Description: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

    Gene: PIK3R1

    分子量
    54,83kDa
    基因ID
    5295
    UniProt
    P27986, Q92569
You are here:
客服