PHF19 抗体 (Internal Region)
-
- 抗原 See all PHF19 抗体
- PHF19 (PHD Finger Protein 19 (PHF19))
-
抗原表位
- Internal Region
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This PHF19 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- PHF19 Antibody detects endogenous levels of total PHF19.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PHF19, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PHF19 Primary Antibody
-
-
- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
-
- 抗原
- PHF19 (PHD Finger Protein 19 (PHF19))
- 别名
- PHF19 (PHF19 产品)
- 别名
- si:dkeyp-51b7.1 antibody, pcl3 antibody, MGC147603 antibody, MTF2L1 antibody, PCL3 antibody, TDRD19B antibody, 3110009G19Rik antibody, 3321402G02Rik antibody, PHD finger protein 19 antibody, Phf19 antibody, PHF19 antibody, phf19 antibody
- 背景
-
Description: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
Gene: PHF19
- 分子量
- 66 kDa
- 基因ID
- 26147
- UniProt
- Q5T6S3
- 途径
- Stem Cell Maintenance
-