PER3 抗体 (Internal Region)
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- 抗原 See all PER3 抗体
- PER3 (Period Homolog 3 (PER3))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PER3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- PER3 Antibody detects endogenous levels of total PER3.
- 预测反应
- Zebrafish
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PER3, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PER3 Primary Antibody
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anti-Period Homolog 3 (PER3) (AA 723-954) antibody
PER3 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4B9D7 unconjugated
anti-Period Homolog 3 (PER3) (AA 1-131) antibodyPER3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Period Homolog 3 (PER3) (AA 1105-1201) antibodyPER3 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3A7 unconjugated
anti-Period Homolog 3 (PER3) (AA 723-954) antibodyPER3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5D5B8 unconjugated
anti-Period Homolog 3 (PER3) antibodyPER3 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Period Homolog 3 (PER3) (AA 1-378) antibodyPER3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Period Homolog 3 (PER3) (AA 1-378) antibodyPER3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Period Homolog 3 (PER3) antibodyPER3 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Period Homolog 3 (PER3) (AA 104-153) antibodyPER3 适用: 人, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PER3 (Period Homolog 3 (PER3))
- 别名
- PER3 (PER3 产品)
- 别名
- period3 antibody, rper3 antibody, GIG13 antibody, 2810049O06Rik antibody, mPer3 antibody, period circadian clock 3 antibody, period circadian regulator 3 antibody, Per3 antibody, PER3 antibody
- 背景
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Description: Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme.
Gene: PER3
- 分子量
- 132kDa
- 基因ID
- 8863
- UniProt
- P56645
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