OTUD7B 抗体 (C-Term)
-
- 抗原 See all OTUD7B 抗体
- OTUD7B (OTU Domain Containing 7B (OTUD7B))
-
抗原表位
- C-Term
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This OTUD7B antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- OTUD7B Antibody detects endogenous levels of total OTUD7B.
- 预测反应
- Pig,Bovine,Sheep,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human OTUD7B, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product OTUD7B Primary Antibody
-
anti-OTU Domain Containing 7B (OTUD7B) (AA 759-858) antibody
OTUD7B 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2B4 unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 235-347) antibodyOTUD7B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 530-700) antibodyOTUD7B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (Middle Region) antibodyOTUD7B 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 1-427) antibodyOTUD7B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 559-608) antibodyOTUD7B 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 612-661) antibodyOTUD7B 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, Pig, 兔, Bat, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 7B (OTUD7B) (AA 757-784), (C-Term) antibodyOTUD7B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
-
- 抗原
- OTUD7B (OTU Domain Containing 7B (OTUD7B))
- 别名
- OTUD7B (OTUD7B 产品)
- 背景
-
Description: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro), however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.
Gene: OTUD7B
- 分子量
- 100 kDa
- 基因ID
- 56957
- UniProt
- Q6GQQ9
-
