OTUB1 抗体 (Internal Region)
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- 抗原 See all OTUB1 抗体
- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This OTUB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- OTUB1 Antibody detects endogenous levels of total OTUB1.
- 预测反应
- Pig,Bovine,Horse,Sheep,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human OTUB1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product OTUB1 Primary Antibody
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anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibody
OTUB1 适用: 人 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 5B8 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2H1 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F7 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-220) antibodyOTUB1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 2-201) antibodyOTUB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) antibodyOTUB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (Center) antibodyOTUB1 适用: 人, 小鼠 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) antibodyOTUB1 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
- 别名
- OTUB1 (OTUB1 产品)
- 别名
- OTB1 antibody, OTU1 antibody, AI850305 antibody, fa19h07 antibody, otub1 antibody, wu:fa19h07 antibody, zgc:92839 antibody, MGC131231 antibody, fb17f04 antibody, otub1l antibody, wu:fb17f04 antibody, zgc:92685 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1 antibody, OTU domain, ubiquitin aldehyde binding 1 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1b antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1 L homeolog antibody, similar to HSPC263 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1a antibody, OTUB1 antibody, Otub1 antibody, otub1b antibody, otub1.L antibody, otub1 antibody, RGD1565010 antibody, otub1a antibody
- 背景
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Description: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.
Gene: OTUB1
- 分子量
- 31 kDa
- 基因ID
- 55611
- UniProt
- Q96FW1
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