NOD2 抗体 (N-Term)
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- 抗原 See all NOD2 抗体
- NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))
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抗原表位
- N-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NOD2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- NOD2 Antibody detects endogenous levels of total NOD2.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human NOD2, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product NOD2 Primary Antibody
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anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 611-910) antibody
NOD2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 251-350) antibodyNOD2 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 460-733) antibodyNOD2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) antibodyNOD2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 1-1040) antibodyNOD2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (C-Term) antibodyNOD2 适用: 人 WB, ELISA, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 251-350) antibody (AbBy Fluor® 488)NOD2 适用: 人 WB, FACS 宿主: 兔 Polyclonal AbBy Fluor® 488
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 1-1040) antibodyNOD2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (Internal Region) antibodyVerified NOD2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) antibodyNOD2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))
- 别名
- NOD2 (NOD2 产品)
- 别名
- ACUG antibody, BLAU antibody, CARD15 antibody, CD antibody, CLR16.3 antibody, IBD1 antibody, NLRC2 antibody, NOD2B antibody, PSORAS1 antibody, Card15 antibody, F830032C23Rik antibody, Nlrc2 antibody, caspase recruitment domain 15 protein antibody, nucleotide binding oligomerization domain containing 2 antibody, nucleotide-binding oligomerization domain containing 2 antibody, TTHERM_01951320 antibody, NOD2 antibody, Nod2 antibody
- 背景
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Description: Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189).
Gene: NOD2
- 分子量
- 100-110 kDa
- 基因ID
- 64127
- UniProt
- Q9HC29
- 途径
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome
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