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MSH2 抗体 (C-Term)

Name: MSH2 抗体 (C-Term)
SKU: ABIN6263384
Availability: OutOfStock

MSH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Hela whole cell lysates, using MSH2 Antibody. (MSH2 抗体 (C-Term))

ABIN6276526 staining HeLa cells by ICC/IF. (MSH2 抗体 (C-Term))

IF/ICC

ABIN6276526 at 1/100 staining Mouse colon tissue by IHC-P. (MSH2 抗体 (C-Term))

IHC

3 images

产品编号 ABIN6263384

发货至: 中国

Datasheet as PDF

抗原 See all MSH2 抗体

MSH2 (Mismatch Repair Protein 2 (MSH2))
抗原表位
15

8

8

7

6

6

6

4

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
79

40

19

6

6

6

4

3

3

3

3

2

2

1

1

1
人, 小鼠, 大鼠
宿主
75

18

1
兔
Compatible Secondaries
克隆类型
71

24
多克隆
标记
60

5

5

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MSH2 antibody is un-conjugated
应用范围
57

36

27

22

21

14

13

11

11

9

7

4

3

2

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

MSH2 Antibody detects endogenous levels of total MSH2.

预测反应

Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human MSH2, corresponding to a region within C-terminal amino acids.

亚型

IgG

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anti-Mismatch Repair Protein 2 (MSH2) (AA 327-427) antibody
MSH2 适用: 人 WB, IHC, FACS, StM 宿主: 小鼠 Monoclonal MSH2-2622 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 1-300) antibody
MSH2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibody
MSH2 适用: 人, 小鼠 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 2E2C7 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 1-934) antibody
MSH2 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 337-583) antibody
MSH2 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 835-934) antibody
MSH2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4B2 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 224-313) antibody
MSH2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal SYP-3551 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibody
MSH2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4F10D6 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 637-665) antibody
MSH2 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 2-254) antibody
MSH2 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

MSH2 (Mismatch Repair Protein 2 (MSH2))

别名

MSH2 (MSH2 产品)

别名

COCA1 antibody, FCC1 antibody, HNPCC antibody, HNPCC1 antibody, LCFS2 antibody, AI788990 antibody, wu:fc06b02 antibody, wu:fc13e09 antibody, zgc:55333 antibody, ATMSH2 antibody, MUTS homolog 2 antibody, msh2 antibody, mutS homolog 2 antibody, mutS homolog 2 (E. coli) antibody, MUTS homolog 2 antibody, mutS homolog 2 L homeolog antibody, MutS protein homolog 2 antibody, MSH2 antibody, Msh2 antibody, msh2 antibody, msh2.L antibody

背景

Description: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Gene: MSH2

分子量

105kDa

基因ID

4436

UniProt

P43246

途径

DNA Damage Repair, Production of Molecular Mediator of Immune Response