MMS19 抗体 (Internal Region)
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- 抗原 See all MMS19 抗体
- MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))
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抗原表位
- Internal Region
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MMS19 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- MMS19 Antibody detects endogenous levels of total MMS19.
- 预测反应
- Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human MMS19, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product MMS19 Primary Antibody
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anti-MMS19 Nucleotide Excision Repair Homolog (MMS19) (AA 1-293) antibody
MMS19 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-MMS19 Nucleotide Excision Repair Homolog (MMS19) (AA 851-950) antibodyMMS19 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))
- 别名
- MMS19 (MMS19 产品)
- 背景
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Description: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).
Gene: MMS19
- 分子量
- 103-113 kDa
- 基因ID
- 64210
- UniProt
- Q96T76
- 途径
- Nuclear Hormone Receptor Binding
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