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- 抗原 See all DIAPH1 抗体
- DIAPH1 (Diaphanous Homolog 1 (DIAPH1))
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适用
- 人, 小鼠, 大鼠, 猴
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DIAPH1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- MDia1 antibody detects endogenous levels of mDia1.
- 交叉反应
- 人, 猴, 小鼠, 大鼠
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human mDia1.
- 亚型
- IgG
- Top Product
- Discover our top product DIAPH1 Primary Antibody
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anti-Diaphanous Homolog 1 (DIAPH1) (C-Term) antibody
DIAPH1 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (N-Term) antibodyDIAPH1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 1-404) antibodyDIAPH1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 389-583) antibodyDIAPH1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 18-52), (N-Term) antibodyDIAPH1 适用: 人 WB 宿主: 兔 Polyclonal RB30760 unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 921-1024) antibodyDIAPH1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 1-404) antibodyDIAPH1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 1-404) antibodyDIAPH1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 921-1024) antibodyDIAPH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A8 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
- 有效期
- 12 months
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- 抗原
- DIAPH1 (Diaphanous Homolog 1 (DIAPH1))
- 别名
- mDia1 (DIAPH1 产品)
- 别名
- DIAPH1 antibody, dia1 antibody, drf1 antibody, dfna1 antibody, diap1 antibody, lfhl1 antibody, DIAPH2 antibody, Diap1 antibody, D18Wsu154e antibody, Dia1 antibody, Diaph1 antibody, Drf1 antibody, mKIAA4062 antibody, p140mDia antibody, DFNA1 antibody, DIA1 antibody, DRF1 antibody, LFHL1 antibody, hDIA1 antibody, diaphanous related formin 1 antibody, diaphanous related formin 2 antibody, diaphanous-related formin 1 antibody, protein diaphanous homolog 1 antibody, DIAPH1 antibody, diaph1 antibody, DIAPH2 antibody, Diaph1 antibody, LOC100457442 antibody
- 背景
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Description: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755).
Gene: DIAPH1
- 分子量
- 140-150, 70 kDa
- 基因ID
- 1729
- UniProt
- O60610
- 途径
- Sensory Perception of Sound
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