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MAGEA2B 抗体 (C-Term)

MAGEA2B 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6263054
发货至: 中国
  • 抗原 See all MAGEA2B 抗体
    MAGEA2B (Melanoma Antigen Family A, 2B (MAGEA2B))
    抗原表位
    C-Term
    适用
    宿主
    • 8
    克隆类型
    • 8
    多克隆
    标记
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    This MAGEA2B antibody is un-conjugated
    应用范围
    ELISA, Western Blotting (WB)
    特异性
    MAGEA2 Antibody detects endogenous levels of total MAGEA2.
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human MAGEA2, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
  • 应用备注
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    MAGEA2B (Melanoma Antigen Family A, 2B (MAGEA2B))
    别名
    MAGEA2, MAGEA2B (MAGEA2B 产品)
    别名
    MAGE2 antibody, MAGEA2 antibody, MAGE family member A2B antibody, MAGEA2B antibody
    背景

    Description: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

    Gene: MAGEA2, MAGEA2B

    分子量
    35 kDa
    基因ID
    266740, 4101
    UniProt
    P43356
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