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LRP4 抗体 (N-Term)

LRP4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6263007
发货至: 中国
  • 抗原 See all LRP4 抗体
    LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
    抗原表位
    • 11
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 24
    • 19
    • 10
    • 2
    人, 小鼠, 大鼠
    宿主
    • 19
    • 16
    • 1
    • 1
    克隆类型
    • 21
    • 16
    多克隆
    标记
    • 14
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LRP4 antibody is un-conjugated
    应用范围
    • 24
    • 16
    • 14
    • 13
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    特异性
    LRP4 Antibody detects endogenous levels of total LRP4.
    预测反应
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human LRP4, corresponding to a region within N-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product LRP4 Primary Antibody
  • 应用备注
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
    别名
    LRP4 (LRP4 产品)
    别名
    CLSS antibody, LRP-4 antibody, LRP10 antibody, MEGF7 antibody, SOST2 antibody, Megf7 antibody, 6430526J12Rik antibody, D230026E03 antibody, mdig antibody, LRP4 antibody, lrp10 antibody, megf7 antibody, LDL receptor related protein 4 antibody, low density lipoprotein receptor-related protein 4 antibody, LRP4 antibody, Lrp4 antibody, lrp4 antibody
    背景

    Description: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).

    Gene: LRP4

    分子量
    212kDa
    基因ID
    4038
    UniProt
    O75096
    途径
    Skeletal Muscle Fiber Development
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