DHX58 抗体 (Internal Region)
Quick Overview for DHX58 抗体 (Internal Region) (ABIN6262957)
抗原
See all DHX58 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- LGP2 Antibody detects endogenous levels of total LGP2.
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预测反应
- Bovine,Horse,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human LGP2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 479-678) antibody
DHX58 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6A6A3 unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 479-678) antibodyDHX58 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3E11F1 unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 389-678) antibodyDHX58 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (C-Term) antibodyVerified DHX58 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) antibodyDHX58 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 1-678) antibodyDHX58 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 389-678) antibodyDHX58 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 1-678) antibodyDHX58 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 35-84) antibodyDHX58 适用: 人, 豚鼠, 马, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (AA 41-69), (N-Term) antibodyDHX58 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB26842 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
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别名
- DHX58
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背景
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Description: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
Gene: DHX58
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分子量
- 77 kDa
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基因ID
- 79132
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UniProt
- Q96C10
抗原
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