KLHL3 抗体 (N-Term)
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- 抗原 See all KLHL3 抗体
- KLHL3 (Kelch-Like 3 (KLHL3))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KLHL3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- KLHL3 Antibody detects endogenous levels of total KLHL3.
- 预测反应
- Bovine,Horse,Sheep,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human KLHL3, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product KLHL3 Primary Antibody
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- 应用备注
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- KLHL3 (Kelch-Like 3 (KLHL3))
- 别名
- KLHL3 (KLHL3 产品)
- 别名
- 7530408C15Rik antibody, AI430941 antibody, EG627648 antibody, PHA2D antibody, RGD1565218 antibody, kelch like family member 3 antibody, kelch-like 3 antibody, kelch-like family member 3 antibody, KLHL3 antibody, Klhl3 antibody
- 背景
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Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).
Gene: KLHL3
- 分子量
- 64 kDa
- 基因ID
- 26249
- UniProt
- Q9UH77
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