ISCU 抗体 (Internal Region)
Quick Overview for ISCU 抗体 (Internal Region) (ABIN6262671)
抗原
See all ISCU 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- ISCU Antibody detects endogenous levels of total ISCU.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ISCU, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) (AA 26-167) antibody
ISCU 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B8-1C4 unconjugated
anti-Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) (AA 1-167) antibodyISCU 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) (AA 138-167), (C-Term) antibodyISCU 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB35591 unconjugated
anti-Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) antibodyISCU 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) antibodyISCU 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) (AA 1-142) antibodyISCU 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) (N-Term) antibodyISCU 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, 小鸡, Hamster, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) (AA 1-167) antibodyISCU 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- ISCU (Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU))
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别名
- ISCU
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背景
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Description: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).
Gene: ISCU
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分子量
- 14-15 kDa,18-19 kDa
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基因ID
- 23479
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UniProt
- Q9H1K1
抗原
-
