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IRF3 抗体 (C-Term)

Name: IRF3 抗体 (C-Term)
SKU: ABIN6262651
Availability: OutOfStock

IRF3 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of IRF3 expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (IRF3 抗体 (C-Term))

ABIN6269358 at 1/100 staining Human lung tissue by IHC-P. (IRF3 抗体 (C-Term))

IHC

IF/ICC

4 images

产品编号 ABIN6262651

发货至: 中国

Datasheet as PDF

抗原 See all IRF3 抗体

IRF3 (Interferon Regulatory Factor 3 (IRF3))
抗原表位
15

15

14

14

14

8

7

5

5

5

4

4

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
144

86

54

31

18

3

2

2

2

1

1

1

1
人
宿主
146

17

2
兔
Compatible Secondaries
克隆类型
133

32
多克隆
标记
89

11

8

7

4

4

4

4

4

4

2

2

2

2

2

2

2

2

2

2

2

2

2
This IRF3 antibody is un-conjugated
应用范围
122

68

36

31

29

27

19

11

10

10

6

4

3

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

IRF3 Antibody detects endogenous levels of total IRF3.

预测反应

Pig,Bovine,Sheep,Dog

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human IRF3, corresponding to a region within C-terminal amino acids.

亚型

IgG

Top Product

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anti-Interferon Regulatory Factor 3 (IRF3) (pSer396) antibody
IRF3 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-260) antibody
IRF3 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3C8 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 51-150) antibody
IRF3 适用: 人, 小鼠, 大鼠, 猴, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-360) antibody
IRF3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (pSer386) antibody
IRF3 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) antibody
IRF3 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 4C3 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1268-1341) antibody
IRF3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (pSer385) antibody
IRF3 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

IRF3 (Interferon Regulatory Factor 3 (IRF3))

别名

IRF3 (IRF3 产品)

别名

irf3 antibody, IRF3 antibody, C920001K05Rik antibody, IRF-3 antibody, interferon regulatory factor 3 antibody, interferon regulatory factor 7 antibody, irf3 antibody, IRF3 antibody, irf-3 antibody, Irf3 antibody, IRF7 antibody

背景

Description: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Gene: IRF3

分子量

57kDa

基因ID

3661

UniProt

Q14653

途径

TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades