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Interleukin enhancer-binding factor 3 (ILF3) (Internal Region) 抗体

ILF3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6262571
发货至: 中国
  • 抗原 See all Interleukin enhancer-binding factor 3 (ILF3) 抗体
    Interleukin enhancer-binding factor 3 (ILF3)
    抗原表位
    • 4
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    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 55
    • 38
    • 34
    • 13
    • 11
    • 11
    • 10
    • 5
    • 5
    • 5
    • 2
    • 2
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    人, 小鼠, 大鼠
    宿主
    • 51
    • 2
    • 1
    克隆类型
    • 45
    • 10
    多克隆
    标记
    • 41
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    非结合性
    应用范围
    • 35
    • 16
    • 10
    • 9
    • 8
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    ILF3 Antibody detects endogenous levels of total ILF3.
    预测反应
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human ILF3, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product ILF3 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    Interleukin enhancer-binding factor 3 (ILF3)
    别名
    ILF3 (ILF3 产品)
    背景

    Description: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 Molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).

    Gene: ILF3

    分子量
    95kDa
    基因ID
    3609
    UniProt
    Q12906
    途径
    M Phase
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