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- 抗原 See all IFIT3 抗体
- IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IFIT3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- IFIT3 Antibody detects endogenous levels of total IFIT3.
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human IFIT3, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product IFIT3 Primary Antibody
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anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 1-490) antibody
IFIT3 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) antibodyIFIT3 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (N-Term) antibodyIFIT3 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) antibodyIFIT3 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 1-490) antibodyIFIT3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 1-490) antibodyIFIT3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 128-331) antibodyIFIT3 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (N-Term) antibodyIFIT3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 51-100) antibodyIFIT3 适用: 人, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) antibodyIFIT3 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 1G1 unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))
- 别名
- IFIT3 (IFIT3 产品)
- 别名
- DKFZp469G2233 antibody, CIG-49 antibody, GARG-49 antibody, IFI60 antibody, IFIT4 antibody, IRG2 antibody, ISG60 antibody, P60 antibody, RIG-G antibody, Ifi49 antibody, P49 antibody, IFIT-3 antibody, interferon induced protein with tetratricopeptide repeats 3 antibody, interferon-induced protein with tetratricopeptide repeats 3 antibody, IFIT3 antibody, Ifit3 antibody
- 背景
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Description: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Gene: IFIT3
- 分子量
- 56 kDa
- 基因ID
- 3437
- UniProt
- O14879
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