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HNRNPA2B1 抗体 (N-Term)

HNRNPA2B1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6262328
发货至: 中国
  • 抗原 See all HNRNPA2B1 抗体
    HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1))
    抗原表位
    • 7
    • 7
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    N-Term
    适用
    • 60
    • 36
    • 30
    • 4
    • 4
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    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 44
    • 15
    • 1
    克隆类型
    • 45
    • 15
    多克隆
    标记
    • 29
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    This HNRNPA2B1 antibody is un-conjugated
    应用范围
    • 48
    • 22
    • 16
    • 15
    • 13
    • 8
    • 6
    • 4
    • 1
    • 1
    • 1
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    HnRNP A2/B1 Antibody detects endogenous levels of total hnRNP A2/B1.
    预测反应
    Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human hnRNP A2/B1, corresponding to a region within N-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product HNRNPA2B1 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1))
    别名
    HNRNPA2B1 (HNRNPA2B1 产品)
    别名
    HNRNPA2 antibody, HNRNPB1 antibody, HNRPA2 antibody, HNRPA2B1 antibody, HNRPB1 antibody, RNPA2 antibody, SNRPB1 antibody, hnrpa2b1 antibody, MGC53135 antibody, HNRNPA2B1 antibody, hnrnpa2 antibody, hnrnpb1 antibody, hnrpa2 antibody, hnrpb1 antibody, rnpa2 antibody, snrpb1 antibody, 9130414A06Rik antibody, Hnrpa2 antibody, Hnrpa2b1 antibody, hnrnp-A antibody, hnRNP antibody, heterogeneous nuclear ribonucleoprotein A2/B1 antibody, heterogeneous nuclear ribonucleoprotein A2/B1 S homeolog antibody, heterogeneous nuclear ribonucleoproteins A2/B1 antibody, HNRNPA2B1 antibody, hnrnpa2b1.S antibody, hnrnpa2b1 antibody, Hnrnpa2b1 antibody, LOC100353281 antibody
    背景

    Description: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).

    Gene: HNRNPA2B1

    分子量
    37kDa
    基因ID
    3181
    UniProt
    P22626
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