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HGS 抗体 (Internal Region)

HGS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6262232
发货至: 中国
  • 抗原 See all HGS 抗体
    HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
    抗原表位
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 44
    • 30
    • 21
    • 3
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 38
    • 5
    • 1
    克隆类型
    • 41
    • 3
    多克隆
    标记
    • 32
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HGS antibody is un-conjugated
    应用范围
    • 36
    • 20
    • 19
    • 15
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    HGS Antibody detects endogenous levels of total HGS.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human HGS, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product HGS Primary Antibody
  • 应用备注
    WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
    别名
    HGS (HGS 产品)
    别名
    HRS antibody, Hrs antibody, fi34f05 antibody, zgc:63492 antibody, wu:fi34f05 antibody, Hgr antibody, ZFYVE8 antibody, CG2903 antibody, Dmel\\CG2903 antibody, HRS-2 antibody, Vps27 antibody, hrs antibody, l(2)23AB5 antibody, l(2)23Ad antibody, l(2)23Ad(Hrs) antibody, vps27 antibody, hgs antibody, hepatocyte growth factor-regulated tyrosine kinase substrate antibody, HGF-regulated tyrosine kinase substrate antibody, Hepatocyte growth factor regulated tyrosine kinase substrate antibody, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog antibody, HGS antibody, Hgs antibody, hgs antibody, Hrs antibody, hgs.L antibody
    背景

    Description: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

    Gene: HGS

    分子量
    86kDa
    基因ID
    9146
    UniProt
    O14964
    途径
    EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
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