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GSDMD 抗体

GSDMD 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6262106
发货至: 中国
  • 抗原 See all GSDMD 抗体
    GSDMD (Gasdermin D (GSDMD))
    适用
    • 19
    • 2
    • 1
    宿主
    • 16
    • 4
    克隆类型
    • 16
    • 4
    多克隆
    标记
    • 16
    • 2
    • 1
    • 1
    This GSDMD antibody is un-conjugated
    应用范围
    • 15
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    GSDMD Antibody detects endogenous levels of total GSDMD.
    预测反应
    Pig,Bovine,Horse,Dog
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human GSDMD.
    亚型
    IgG
    Top Product
    Discover our top product GSDMD Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200 IF/ICC 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    GSDMD (Gasdermin D (GSDMD))
    别名
    GSDMD (GSDMD 产品)
    别名
    GSDMDC1 antibody, GSDMD antibody, DF5L antibody, DFNA5L antibody, 1810036L03Rik antibody, AW558049 antibody, Dfna5l antibody, Gsdmdc1 antibody, M2-4 antibody, gasdermin D antibody, GSDMD antibody, Gsdmd antibody
    背景

    Description: Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).

    Gene: GSDMD

    分子量
    50-53 kDa
    基因ID
    79792
    UniProt
    P57764
    途径
    Inflammasome
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