GRB7 抗体 (Internal Region)
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- 抗原 See all GRB7 抗体
- GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
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抗原表位
- Internal Region
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GRB7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- GRB7 Antibody detects endogenous levels of total GRB7.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human GRB7, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product GRB7 Primary Antibody
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
- 别名
- GRB7 (GRB7 产品)
- 别名
- GRB7 antibody, mKIAA4028 antibody, growth factor receptor bound protein 7 antibody, GRB7 antibody, Grb7 antibody
- 背景
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Description: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
Gene: GRB7
- 分子量
- 60 kDa
- 基因ID
- 2886
- UniProt
- Q14451
- 途径
- EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
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