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Golgin A2 (GOLGA2) (N-Term) 抗体

GOLGA2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6262002
发货至: 中国
  • 抗原 See all Golgin A2 (GOLGA2) 抗体
    Golgin A2 (GOLGA2)
    抗原表位
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    N-Term
    适用
    • 44
    • 30
    • 30
    • 3
    人, 小鼠, 大鼠
    宿主
    • 36
    • 8
    克隆类型
    • 38
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    多克隆
    标记
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    非结合性
    应用范围
    • 22
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    GM130 Antibody detects endogenous levels of total GM130.
    预测反应
    Chicken
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human GM130, corresponding to a region within N-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product GOLGA2 Primary Antibody
  • 应用备注
    WB 1:1000-3000, IHC 1:200, IF/ICC 1:50-200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    Golgin A2 (GOLGA2)
    别名
    GOLGA2 (GOLGA2 产品)
    别名
    gm130 antibody, MGC81213 antibody, AW555139 antibody, GM130 antibody, mKIAA4150 antibody, Gm130 antibody, golgin A2 S homeolog antibody, golgin A2 antibody, golgi autoantigen, golgin subfamily a, 2 antibody, golga2.S antibody, GOLGA2 antibody, Golga2 antibody
    背景

    Description: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).

    Gene: GOLGA2

    分子量
    130 kDa
    基因ID
    2801
    UniProt
    Q08379
    途径
    SARS-CoV-2 Protein Interactome
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