FOXP3 抗体 (C-Term)
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- 抗原 See all FOXP3 抗体
- FOXP3 (Forkhead Box P3 (FOXP3))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FOXP3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- 特异性
- Foxp3 Antibody detects endogenous levels of total Foxp3.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human Foxp3, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product FOXP3 Primary Antibody
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anti-Forkhead Box P3 (FOXP3) (AA 190-412) antibody
FOXP3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (C-Term) antibodyFOXP3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (C-Term) antibodyVerified FOXP3 适用: 小鼠 FACS, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 297-431) antibodyFOXP3 适用: 人 FACS, ELISA, IHC 宿主: 小鼠 Monoclonal 4F12A2 unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 191-412) antibodyFOXP3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (C-Term) antibodyVerified FOXP3 适用: 人 WB, FACS, ELISA, IHC, IF, ICC 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (N-Term) antibodyFOXP3 适用: 人, 小鼠, 大鼠, Cow, Pig, 马, 兔, 绵羊, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 191-412) antibodyFOXP3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 1-431) antibodyFOXP3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) antibody (APC)FOXP3 适用: 人, 小鼠 FACS 宿主: 小鼠 Monoclonal 3G3 APC
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, IP, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- FOXP3 (Forkhead Box P3 (FOXP3))
- 别名
- FOXP3 (FOXP3 产品)
- 别名
- foxp3 antibody, FOXP3 antibody, AIID antibody, DIETER antibody, IPEX antibody, PIDX antibody, XPID antibody, JM2 antibody, scurfin antibody, sf antibody, RGD1562112 antibody, forkhead box P3 antibody, forkhead box P3a antibody, forkhead box P3 L homeolog antibody, FOXP3 antibody, foxp3a antibody, foxp3 antibody, foxp3.L antibody, Foxp3 antibody
- 背景
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Description: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).
Gene: FOXP3
- 分子量
- 47 kDa
- 基因ID
- 50943
- UniProt
- Q9BZS1
- 途径
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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