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FOXP1 抗体 (C-Term)

FOXP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6261807
发货至: 中国
  • 抗原 See all FOXP1 抗体
    FOXP1 (Forkhead Box P1 (FOXP1))
    抗原表位
    • 16
    • 14
    • 12
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 75
    • 48
    • 25
    • 19
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 81
    • 12
    • 1
    克隆类型
    • 71
    • 22
    • 1
    多克隆
    标记
    • 43
    • 8
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This FOXP1 antibody is un-conjugated
    应用范围
    • 47
    • 38
    • 33
    • 31
    • 12
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    FOXP1 Antibody detects endogenous levels of total FOXP1.
    预测反应
    Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human FOXP1, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product FOXP1 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    FOXP1 (Forkhead Box P1 (FOXP1))
    别名
    FOXP1 (FOXP1 产品)
    别名
    12CC4 antibody, QRF1 antibody, hFKH1B antibody, 3110052D19Rik antibody, 4932443N09Rik antibody, AI461938 antibody, AW494214 antibody, foxp1 antibody, im:7139058 antibody, wu:fc83a06 antibody, FOXP1 antibody, MGC145686 antibody, 12cc4 antibody, fkh1b antibody, hspc215 antibody, qrf1 antibody, xlfoxp1 antibody, im:7146611 antibody, wu:fb97f01 antibody, zgc:154010 antibody, forkhead box P1 antibody, forkhead box P1b antibody, forkhead box P1 S homeolog antibody, forkhead box P1a antibody, FOXP1 antibody, Foxp1 antibody, foxp1b antibody, foxp1 antibody, foxp1.S antibody, foxp1a antibody
    背景

    Description: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program, the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity, may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence, the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions, repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis, the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).

    Gene: FOXP1

    分子量
    75kDa
    基因ID
    27086
    UniProt
    Q9H334
    途径
    Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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