FANCM 抗体 (Internal Region)
-
- 抗原 See all FANCM 抗体
- FANCM (Fanconi Anemia Complementation Group M (FANCM))
-
抗原表位
- Internal Region
-
适用
- 人, 大鼠, 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This FANCM antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- FANCM Antibody detects endogenous levels of total FANCM.
- 预测反应
- Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human FANCM, corresponding to a region within the internal amino acids.
- 亚型
- IgG
-
anti-Fanconi Anemia Complementation Group M (FANCM) (AA 1-669) antibody
FANCM 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Fanconi Anemia Complementation Group M (FANCM) (AA 1752-1783) antibodyFANCM 适用: 人 WB 宿主: 兔 Polyclonal RB54125 unconjugated
anti-Fanconi Anemia Complementation Group M (FANCM) (AA 390-660) antibodyFANCM 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
-
- 抗原
- FANCM (Fanconi Anemia Complementation Group M (FANCM))
- 别名
- FANCM (FANCM 产品)
- 别名
- FAAP250 antibody, KIAA1596 antibody, AI427100 antibody, C730036B14Rik antibody, D12Ertd364e antibody, Fanconi anemia complementation group M antibody, hypothetical protein antibody, Fanconi anemia, complementation group M antibody, FANCM antibody, PGTG_17854 antibody, Fancm antibody
- 背景
-
Description: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434).
Gene: FANCM
- 分子量
- 232 kDa
- 基因ID
- 57697
- UniProt
- Q8IYD8
- 途径
- DNA Damage Repair
-
