EZH2 抗体 (Internal Region)
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- 抗原 See all EZH2 抗体
- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EZH2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- EZH2 Antibody detects endogenous levels of total EZH2.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human EZH2, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product EZH2 Primary Antibody
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anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 51-285) antibody
EZH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-194) antibodyEZH2 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6G4F4 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-296), (N-Term) antibodyEZH2 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB23144 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 144CT2-1-1-5 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 410-440) antibodyEZH2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2921 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-250) antibodyEZH2 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人 WB 宿主: 小鼠 Monoclonal EZH2-2536 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-250) antibodyEZH2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
- 别名
- EZH2 (EZH2 产品)
- 别名
- ENX-1 antibody, ENX1 antibody, EZH1 antibody, EZH2b antibody, KMT6 antibody, KMT6A antibody, WVS antibody, WVS2 antibody, eya2 antibody, im:7149338 antibody, zgc:136376 antibody, zgc:152758 antibody, EZH2 antibody, enx-1 antibody, enx1 antibody, ezh1 antibody, kmt6 antibody, xez antibody, Enx-1 antibody, Enx1h antibody, mKIAA4065 antibody, ezh2 antibody, olezh2 antibody, enhancer of zeste 2 polycomb repressive complex 2 subunit antibody, enhancer of zeste 2 polycomb repressive complex 2 subunit L homeolog antibody, enhancer of zeste 2 polycomb repressive complex 2 subunit S homeolog antibody, EZH2 antibody, ezh2 antibody, Ezh2 antibody, ezh2.L antibody, ezh2.S antibody
- 背景
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Description: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer, involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.
Gene: EZH2
- 分子量
- 85 kDa
- 基因ID
- 2146
- UniProt
- Q15910
- 途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
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