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ERK1/2 抗体

Name: ERK1/2 抗体
SKU: ABIN6261598
Availability: OutOfStock

MAPK1/3 适用: 人, 小鼠, 大鼠, Cow, Pig, 斑马鱼, 犬, 绵羊, 鱼, 马, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis on COLO205 cell lysate using ERK1/2 Antibody,The lane on the left is treated with the antigen-specific peptide. (ERK1/2 抗体)

ABIN6266535 staining lovo cells by ICC/IF. (ERK1/2 抗体)

IF/ICC

Western blot analysis of extracts of various celllines,using erk1/2 antibody. (ERK1/2 抗体)

Western blot analysis on Hela cell lysate using ERK1/2 Antibody (ERK1/2 抗体)

Western blot analysis of extracts from various samples, using ERK1/2 Antibody. (ERK1/2 抗体)

5 images

(15 references)

产品编号 ABIN6261598

发货至: 中国

Datasheet as PDF

抗原 See all ERK1/2 (MAPK1/3) 抗体

ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
适用
186

154

151

22

22

17

6

3

2

2

2

1

1

1

1
人, 小鼠, 大鼠, Cow, Pig, 斑马鱼, 犬, 绵羊, 鱼, 马, 猴
宿主
137

50

4
兔
Compatible Secondaries
克隆类型
134

57
多克隆
标记
90

12

8

5

5

5

5

5

5

5

5

5

5

5

4

3

3

3

3

3

3

2

1

1
This ERK1/2 antibody is un-conjugated
应用范围
149

65

51

49

47

39

22

21

19

13

4

3

3
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

ERK1/2 antibody detects endogenous levels of total ERK1/2

交叉反应

牛, 犬, 鱼, 马, 人, 猴, 小鼠, 猪, 大鼠, 绵羊, 斑马鱼

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human ERK1/2

亚型

IgG

Top Product

Discover our top product MAPK1/3 Primary Antibody
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 301-358) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 300-380) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠, Cow WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr183), (pTyr185) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr185), (pThr202) antibody
MAPK1/3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (C-Term) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibody
MAPK1/3 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 3F8 unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr183), (pTyr185) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠, 小鸡 WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠, Cow, 小鸡, 非洲爪蟾, 绵羊, Drosophila melanogaster WB, IHC (p), FACS, IP 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (phosphospecific) antibody
MAPK1/3 适用: 人, 小鼠, 大鼠 WB, ELISA, IP 宿主: 兔 Monoclonal G15-B unconjugated

应用备注

WB: 1:1000~1:5000 IHC: 1:100~1:500 IF 1:200

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

PBS,  pH 7.4,50 % glycerol.
Deng, Cheng, Wu, Wang, Zhou, Huang: "Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells." in: Neurochemical research, Vol. 42, Issue 8, pp. 2246-2256, (2018) (PubMed).

Li, Xiong, Xu, Duan, Yang, Zhou, Tu: "miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway." in: Oncotarget, Vol. 8, Issue 20, pp. 32566-32575, (2018) (PubMed).

Peng, Wu, Deng, Zhou, Song, Yang, Zhang, Xu, Xia, Cai, Liu, Peng: "MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)." in: Oncotarget, Vol. 8, Issue 41, pp. 70550-70563, (2018) (PubMed).

Liu, Huang, Jin, Zhou, Chen, Li, Chen, Li, Yao, Li, Lan, Ye, Wang: "MicroRNA-370 inhibits the growth and metastasis of lung cancer by down-regulating epidermal growth factor receptor expression." in: Oncotarget, Vol. 8, Issue 50, pp. 88139-88151, (2018) (PubMed).

Zhao, Fu, Sun, Liu: "Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia." in: IUBMB life, Vol. 70, Issue 1, pp. 60-70, (2018) (PubMed).

Chai, Bai, Li, Chen, Zhang: "Biological functions of lung cancer cells are suppressed in co-culture with mesenchymal stem cells isolated from umbilical cord." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 1076-1080, (2018) (PubMed).

Liu, Geng, Zhang, Wang, Zhang, Duan, Zhang: "Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway." in: Marine drugs, Vol. 16, Issue 3, (2018) (PubMed).

Xin, Cao, Shao, Zhang, Zhang, Wang, Liang, Shao, Qi, Li, Zhang, Yang, Sun, Zhang, Jia, Wang: "Chemokine CXCL3 mediates prostate cancer cells proliferation, migration and gene expression changes in an autocrine/paracrine fashion." in: International urology and nephrology, Vol. 50, Issue 5, pp. 861-868, (2018) (PubMed).

Huang, Song, Tao, Shao, Zeng, Xu, Qi, Sun: "Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells." in: PLoS ONE, Vol. 13, Issue 4, pp. e0195610, (2018) (PubMed).

Wang, Li, Chen, Yang: "Umbilical cord‑derived mesenchymal stem cells can inhibit the biological functions of melanoma A375 cells." in: Oncology reports, Vol. 40, Issue 1, pp. 511-517, (2018) (PubMed).

Sun, Wang, Song: "Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells." in: Molecular medicine reports, Vol. 18, Issue 2, pp. 1405-1414, (2018) (PubMed).

Lu, Jia, Zu, Zhang, Zhao, Shi: "Inhibition of the cyclophilin A-CD147 interaction attenuates right ventricular injury and dysfunction after acute pulmonary embolism in rats." in: The Journal of biological chemistry, Vol. 293, Issue 31, pp. 12199-12208, (2018) (PubMed).

Wu, Feng, Yang, Zhan, Xu, Hu, Zhu, Zhou: "Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mice: the underlying mechanism." in: Neural regeneration research, Vol. 13, Issue 9, pp. 1594-1601, (2018) (PubMed).

Zou, Xiang, Wang, Peng, Wei: "Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model." in: BioMed research international, Vol. 2016, pp. 5436738, (2017) (PubMed).

Huang, Yuan, Wu, Huang: "Estrogen regulates excitatory amino acid carrier 1 (EAAC1) expression through sphingosine kinase 1 (SphK1) transacting FGFR-mediated ERK signaling in rat C6 astroglial cells." in: Neuroscience, Vol. 319, pp. 9-22, (2016) (PubMed).
抗原

ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))

别名

ERK1/2 (MAPK1/3 产品)

别名

erk1/2 antibody, mitogen-activated protein kinase antibody, erk1/2 antibody

背景

Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Gene: MAPK3

分子量

42kDa,44kDa

基因ID

5595

UniProt

P27361, P28482