DGCR8 抗体 (C-Term)
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- 抗原 See all DGCR8 抗体
- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DGCR8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- DGCR8 Antibody detects endogenous levels of total DGCR8.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human DGCR8, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product DGCR8 Primary Antibody
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anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibody
DGCR8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 675-771) antibodyDGCR8 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4G3 unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 675-771) antibodyDGCR8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 180-229) antibodyDGCR8 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (N-Term) antibodyDGCR8 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 439-466) antibodyDGCR8 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) antibodyDGCR8 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 2H2 unconjugated Recombinant Antibody
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (pSer377) antibodyDGCR8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
- 别名
- DGCR8 (DGCR8 产品)
- 别名
- MGC78846 antibody, DGCR8 antibody, gy1 antibody, dgcrk6 antibody, C22orf12 antibody, DGCRK6 antibody, Gy1 antibody, pasha antibody, D16H22S1742E antibody, D16H22S788E antibody, D16Wis2 antibody, N41 antibody, Vo59c07 antibody, si:ch211-106a19.4 antibody, wu:fc23f08 antibody, wu:fc38f06 antibody, DGCR8 microprocessor complex subunit L homeolog antibody, DiGeorge syndrome critical region gene 8 antibody, DGCR8 microprocessor complex subunit antibody, DGCR8, microprocessor complex subunit antibody, microRNA 3618 antibody, dgcr8.L antibody, DGCR8 antibody, dgcr8 antibody, Dgcr8 antibody, MIR3618 antibody
- 背景
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Description: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity).
Gene: DGCR8
- 分子量
- 100kDa
- 基因ID
- 54487
- UniProt
- Q8WYQ5
- 途径
- Regulatory RNA Pathways
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