DCLRE1C 抗体 (C-Term)
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- 抗原 See all DCLRE1C 抗体
- DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DCLRE1C antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- DCLRE1C Antibody detects endogenous levels of total DCLRE1C.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human DCLRE1C, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
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anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 21-50) antibody
DCLRE1C 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-495) antibodyDCLRE1C 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 301-400) antibodyDCLRE1C 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 1-434) antibodyDCLRE1C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 396-445) antibodyDCLRE1C 适用: 人, 大鼠, 豚鼠, 马, 犬, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (N-Term) antibodyDCLRE1C 适用: 人, 小鼠, 大鼠, 豚鼠, 马, Cow, 兔, 斑马鱼, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 21-50), (N-Term) antibodyDCLRE1C 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB24410 unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-531), (pSer516) antibodyDCLRE1C 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-531) antibodyDCLRE1C 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 28-58), (N-Term) antibodyDCLRE1C 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))
- 别名
- DCLRE1C (DCLRE1C 产品)
- 别名
- artemis antibody, A-SCID antibody, DCLREC1C antibody, RS-SCID antibody, SCIDA antibody, SNM1C antibody, hSNM1C antibody, Snm1l antibody, nuclease antibody, 9930121L06Rik antibody, AI661365 antibody, Art antibody, DNA cross-link repair 1C antibody, DCLRE1C antibody, Dclre1c antibody
- 背景
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Description: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Gene: DCLRE1C
- 分子量
- 78kDa
- 基因ID
- 64421
- UniProt
- Q96SD1
- 途径
- DNA Damage Repair
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