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DAXX 抗体 (C-Term)

Name: DAXX 抗体 (C-Term)
SKU: ABIN6261227
Availability: OutOfStock

DAXX 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Daxx expression in 293 cells (DAXX 抗体 (C-Term))

ABIN6268967 at 1/100 staining Mouse lung tissue by IHC-P. (DAXX 抗体 (C-Term))

IHC

IF/ICC

3 images

产品编号 ABIN6261227

发货至: 中国

Datasheet as PDF

抗原 See all DAXX 抗体

DAXX (Death-Domain Associated Protein (DAXX))
抗原表位
23

21

16

16

15

15

8

5

4

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
174

62

48

8

2

1

1

1

1

1

1

1

1
人, 小鼠
宿主
157

18
兔
Compatible Secondaries
克隆类型
148

27
多克隆
标记
63

8

8

8

6

6

6

6

6

6

6

6

6

6

6

3

3

3

3

3

3

3

1
This DAXX antibody is un-conjugated
应用范围
147

78

78

42

35

27

20

19

17

11

7

3

3

2

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Daxx Antibody detects endogenous levels of total Daxx.

预测反应

Bovine,Horse,Dog

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human Daxx, corresponding to a region within C-terminal amino acids.

亚型

IgG

Top Product

Discover our top product DAXX Primary Antibody
anti-Death-Domain Associated Protein (DAXX) (AA 561-660) antibody
DAXX 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4C2 unconjugated

anti-Death-Domain Associated Protein (DAXX) (AA 558-740) antibody
DAXX 适用: 人 WB, ICC 宿主: 小鼠 Monoclonal DAXX-01 unconjugated

anti-Death-Domain Associated Protein (DAXX) antibody
DAXX 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 7A11 unconjugated

anti-Death-Domain Associated Protein (DAXX) (AA 56-345) antibody
DAXX 适用: 人, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Death-Domain Associated Protein (DAXX) antibody
DAXX 适用: 人 WB, IF, EIA 宿主: 小鼠 Monoclonal 7A11 unconjugated

anti-Death-Domain Associated Protein (DAXX) (pSer213) antibody
DAXX 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Death-Domain Associated Protein (DAXX) (pSer495) antibody
DAXX 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Death-Domain Associated Protein (DAXX) (AA 1-740) antibody
DAXX 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Death-Domain Associated Protein (DAXX) (AA 580-740) antibody
DAXX 适用: 人 WB, ICC, IP 宿主: 小鼠 Monoclonal DAXX-03 unconjugated

anti-Death-Domain Associated Protein (DAXX) (Center) antibody
DAXX 适用: 人, 猴 WB, IHC, IF, IP, IC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

DAXX (Death-Domain Associated Protein (DAXX))

别名

DAXX (DAXX 产品)

别名

BING2 antibody, DAP6 antibody, EAP1 antibody, LOC100226911 antibody, daxx antibody, si:dz179b20.7 antibody, wu:fd15c03 antibody, death domain associated protein antibody, Fas death domain-associated protein antibody, 28S ribosomal protein S29, mitochondrial antibody, death-domain associated protein antibody, death-associated protein 6 L homeolog antibody, DAXX antibody, Daxx antibody, LOC100226911 antibody, daxx.L antibody, daxx antibody

背景

Description: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity, the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs), the process is independent of ATRX and facilitated by ASF1A, PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes, the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915).
Gene: DAXX

分子量

82 kDa

基因ID

1616

UniProt

Q9UER7

途径

Intracellular Steroid Hormone Receptor Signaling Pathway