DAP Kinase 1 抗体 (Internal Region)
-
- 抗原 See all DAP Kinase 1 (DAPK1) 抗体
- DAP Kinase 1 (DAPK1) (Death-Associated Protein Kinase 1 (DAPK1))
-
抗原表位
- Internal Region
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This DAP Kinase 1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- DAPK1 Antibody detects endogenous levels of total DAPK1.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human DAPK1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product DAPK1 Primary Antibody
-
anti-Death-Associated Protein Kinase 1 (DAPK1) (AA 1360-1389), (C-Term) antibody
DAPK1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB3033 unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (AA 1331-1430) antibodyDAPK1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (AA 1211-1310) antibodyDAPK1 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) antibodyDAPK1 适用: 人, 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) antibodyDAPK1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (Ser296) antibodyDAPK1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (N-Term) antibodyDAPK1 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (AA 1141-1430) antibodyDAPK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) antibodyDAPK1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Death-Associated Protein Kinase 1 (DAPK1) (N-Term) antibodyDAPK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
-
- 抗原
- DAP Kinase 1 (DAPK1) (Death-Associated Protein Kinase 1 (DAPK1))
- 别名
- DAPK1 (DAPK1 产品)
- 别名
- DAPK1 antibody, MGC81366 antibody, si:ch211-66i11.1 antibody, wu:fj09c03 antibody, dapk antibody, MGC83745 antibody, 2310039H24Rik antibody, 2810425C21Rik antibody, AI642003 antibody, D13Ucla1 antibody, DAP-Kinase antibody, DAPK antibody, death-associated protein kinase 1 antibody, death associated protein kinase 1 L homeolog antibody, death associated protein kinase 1 antibody, death associated protein kinase 1 S homeolog antibody, LOC427465 antibody, dapk1.L antibody, DAPK1 antibody, dapk1 antibody, dapk1.S antibody, Dapk1 antibody
- 背景
-
Description: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca2+ influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.
Gene: DAPK1
- 分子量
- 160kDa
- 基因ID
- 1612
- UniProt
- P53355
- 途径
- MAPK Pathway, Interferon-gamma Pathway
-
