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CYLD 抗体 (C-Term)

Name: CYLD 抗体 (C-Term)
SKU: ABIN6261163
Availability: OutOfStock

CYLD 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

ABIN6273037 at 1/100 staining Human brain cancer tissue by IHC-P. (CYLD 抗体 (C-Term))

IHC

Western blot analysis of extracts of HEK-293 cells, using CYLD antibody. (CYLD 抗体 (C-Term))

2 images

产品编号 ABIN6261163

发货至: 中国

Datasheet as PDF

抗原 See all CYLD 抗体

CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))
抗原表位
15

6

5

2

2

1

1

1

1

1

1

1

1

1

1
C-Term
适用
43

21

16

1

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
37

6

1
兔
Compatible Secondaries
克隆类型
38

6
多克隆
标记
20

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CYLD antibody is un-conjugated
应用范围
29

14

6

5

4

4

3

3

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

特异性

CYLD Antibody detects endogenous levels of total CYLD.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human CYLD, corresponding to a region within C-terminal amino acids.

亚型

IgG

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CYLD 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (C-Term) antibody
CYLD 适用: 人, 小鼠 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 204-358) antibody
CYLD 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5F7F4 unconjugated

anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (pSer418) antibody
CYLD 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 269-435), (C-Term) antibody
CYLD 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 32-45) antibody
CYLD 适用: 人, 小鼠, Hamster, 豚鼠, 马, 猴, 小鸡, 兔, Cow, 犬 WB, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 305-582) antibody
CYLD 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 1667CT857-3-6-1 unconjugated

anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 854-953) antibody
CYLD 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 3A9 unconjugated

anti-Cylindromatosis (Turban Tumor Syndrome) (CYLD) (AA 854-953) antibody
CYLD 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2C3 unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

别名

CYLD (CYLD 产品)

别名

BRSS antibody, CDMT antibody, CYLD1 antibody, CYLDI antibody, EAC antibody, MFT antibody, MFT1 antibody, SBS antibody, TEM antibody, USPL2 antibody, 2010013M14Rik antibody, 2900009M21Rik antibody, C130039D01Rik antibody, mKIAA0849 antibody, cyld antibody, LRRGT00003 antibody, Rp1 antibody, Rp1h antibody, CYLD lysine 63 deubiquitinase antibody, cylindromatosis (turban tumor syndrome), a antibody, CYLD antibody, Cyld antibody, cylda antibody

背景

Description: Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26670046, PubMed:26997266).
Gene: CYLD

分子量

110 kDa

基因ID

1540

UniProt

Q9NQC7

途径

Apoptosis, Activation of Innate immune Response