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- 抗原 See all CREB3L1 抗体
- CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CREB3L1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- CREB3L1,OASIS Antibody detects endogenous levels of total CREB3L1,OASIS.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CREB3L1,OASIS, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CREB3L1 Primary Antibody
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anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 396-500) antibody
CREB3L1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (C-Term) antibodyVerified CREB3L1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 481-509), (C-Term) antibodyCREB3L1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19585 unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 1-519) antibodyCREB3L1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (C-Term) antibodyCREB3L1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) antibodyCREB3L1 适用: 人, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 488-517), (C-Term) antibodyCREB3L1 适用: 人, 小鼠 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 1-519) antibodyCREB3L1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 43-92) antibodyCREB3L1 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (N-Term) antibodyCREB3L1 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))
- 别名
- CREB3L1 (CREB3L1 产品)
- 别名
- CREB3L1 antibody, OASIS antibody, Oasis antibody, diacylglycerol kinase-like antibody, cAMP responsive element binding protein 3 like 1 antibody, cAMP responsive element binding protein 3-like 1 antibody, LOC423198 antibody, CREB3L1 antibody, Creb3l1 antibody
- 背景
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Description: Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401).
Gene: CREB3L1
- 分子量
- 55-58 kDa and 84 kDa
- 基因ID
- 90993
- UniProt
- Q96BA8
- 途径
- Thyroid Hormone Synthesis, Chromatin Binding
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