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Clusterin 抗体 (Internal Region)

Name: Clusterin 抗体 (Internal Region)
SKU: ABIN6260901
Availability: OutOfStock

CLU 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts from hepg2, using CLU Antibody. (Clusterin 抗体 (Internal Region))

IF/ICC

ABIN6276686 at 1/100 staining Mouse colon tissue by IHC-P. (Clusterin 抗体 (Internal Region))

IHC

Western blot analysis of extracts of Y79, using CLU antibody. (Clusterin 抗体 (Internal Region))

4 images

产品编号 ABIN6260901

发货至: 中国

Datasheet as PDF

抗原 See all Clusterin (CLU) 抗体

Clusterin (CLU)
抗原表位
14

10

9

8

7

7

6

6

4

4

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Internal Region
适用
91

27

26

12

7

7

2

1

1

1
人, 大鼠, 小鼠
宿主
83

39

7

6

2

1
兔
Compatible Secondaries
克隆类型
98

38

1
多克隆
标记
77

26

18

4

3

3

1

1

1

1

1

1

1
This Clusterin antibody is un-conjugated
应用范围
113

69

58

22

20

20

18

13

8

6

6

5

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

特异性

CLU Antibody detects endogenous levels of total CLU.

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human CLU, corresponding to a region within the internal amino acids.

亚型

IgG

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anti-Clusterin (CLU) (AA 331-449) antibody
CLU 适用: 人, 大鼠, 小鼠 ELISA, IHC (p), FACS, IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 229-446) antibody
CLU 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 227-448) antibody
CLU 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 228-449) antibody
CLU 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 226-447) antibody
CLU 适用: 兔 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D4 unconjugated

anti-Clusterin (CLU) (C-Term) antibody
Verified CLU 适用: 人 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 23-120) antibody
CLU 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Clusterin (CLU) (AA 227-447) antibody
CLU 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated

anti-Clusterin (CLU) (AA 402-501) antibody
CLU 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A11 unconjugated

anti-Clusterin (CLU) (C-Term) antibody
Verified CLU 适用: 大鼠, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

Clusterin (CLU)

别名

CLU (CLU 产品)

别名

LOC100136120 antibody, clu antibody, MGC53055 antibody, zgc:73352 antibody, xclu antibody, MGC89163 antibody, CLU antibody, APO-J antibody, APOJ antibody, CLI antibody, CLU1 antibody, CLU2 antibody, KUB1 antibody, NA1/NA2 antibody, SGP-2 antibody, SGP2 antibody, SP-40 antibody, TRPM-2 antibody, TRPM2 antibody, DAG antibody, RATTRPM2B antibody, SP40 antibody, TRPM2B antibody, Trpm2 antibody, Trpmb antibody, AI893575 antibody, ApoJ antibody, Cli antibody, D14Ucla3 antibody, Sgp-2 antibody, Sgp2 antibody, Sugp-2 antibody, GP80 antibody, gpIII antibody, 40 antibody, clusterin-1 antibody, clusterin L homeolog antibody, clusterin antibody, Clusterin antibody, LOC100136120 antibody, clu.L antibody, clu antibody, CLU antibody, clus antibody, Clu antibody, LOC101113728 antibody

背景

Description: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
Gene: CLU

分子量

53kDa

基因ID

1191

UniProt

P10909

途径

Apoptosis, Negative Regulation of intrinsic apoptotic Signaling