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- 抗原 See all CCDC22 抗体
- CCDC22 (Coiled-Coil Domain Containing 22 (CCDC22))
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抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CCDC22 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- CCDC22 Antibody detects endogenous levels of total CCDC22.
- 预测反应
- Pig,Horse,Sheep,Rabbit,Dog,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CCDC22, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
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anti-Coiled-Coil Domain Containing 22 (CCDC22) (N-Term) antibody
CCDC22 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil Domain Containing 22 (CCDC22) (AA 530-558), (C-Term) antibodyCCDC22 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33346 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CCDC22 (Coiled-Coil Domain Containing 22 (CCDC22))
- 别名
- CCDC22 (CCDC22 产品)
- 别名
- CXorf37 antibody, AI481216 antibody, DXImx40e antibody, Ppp1r3f antibody, Sfc22 antibody, RGD1560910 antibody, zgc:114058 antibody, coiled-coil domain containing 22 antibody, CCDC22 antibody, Ccdc22 antibody, ccdc22 antibody
- 背景
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Description: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation, the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).
Gene: CCDC22
- 分子量
- 71 kDa
- 基因ID
- 28952
- UniProt
- O60826
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