Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (N-Term) 抗体
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- 抗原 See all Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) 抗体
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- CBLB Antibody detects endogenous levels of total CBLB.
- 预测反应
- Pig,Horse,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CBLB, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CBLB Primary Antibody
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anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 101-200) antibody
CBLB 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-350) antibodyCBLB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 103-130) antibodyCBLB 适用: 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21574 unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) antibodyCBLB 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (C-Term) antibodyCBLB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) antibodyCBLB 适用: 人 WB, DB 宿主: 小鼠 Monoclonal 246C5a unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
- 别名
- CBLB (CBLB 产品)
- 别名
- rnf56 antibody, cblb antibody, AI429560 antibody, AI851073 antibody, Cbl-b antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog antibody, Casitas B-lineage lymphoma b antibody, Cbl proto-oncogene B antibody, cblb.S antibody, cblb.L antibody, Cblb antibody, CBLB antibody
- 背景
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Description: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Gene: CBLB
- 分子量
- 109kDa
- 基因ID
- 868
- UniProt
- Q13191
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